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本文运用ＥＬＩＳＡ法分别测定了９名正常献血员、１５例类风关患者血浆及其中３例患者关节积液中的纤维结合蛋白总含量（ＦＮＴ）、细胞型纤维结合蛋白（ＦＮＡ＋）的含量。结果显示类风关患者血浆中ＦＮＡ＋的含量高于对照组（Ｐ＞０．０５）。５３％患者（８例）血浆中ＦＡＡ＋含量高于正常值，而合并有血管炎或干燥综合征的患者ＦＮＡ＋含量明显高于无合并症者（Ｐ＜０．０１）。关节积．液中ＦＮＡ＋与ＦＮＴ的比值明显高于血浆中ＦＮＡ＋与ＦＮＴ比值，结果提示，在类风关的病变过程中，关节局部有ＦＮＡ＋生物合成的加快，部分ＦＮＡ＋进而进入血液循环，导致血浆中这一型纤维结合蛋白含量的增高。
In this paper, the content of fibronectin (FNT) and cell-bound fibronectin (FNA) in nine normal blood donors and fifteen patients with rheumatoid arthritis were measured by ELISA. The results showed that the plasma level of FNA + in patients with wind-off was higher than that in the control group (P> 0.05). The plasma levels of FAA + were higher in 53% of patients (8 cases) than in normal controls, while those with vasculitis or Sjogren’s syndrome were significantly higher than those without complications (P <0.01). Joint product. The ratio of FNA + to FNT in fluid was significantly higher than the ratio of FNA + to FNT in plasma. The results suggest that FNA + biosynthesis in the joints is accelerated and some FNA + Type fiber binding protein content increased.