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作者采用荧光免疫表型和间期细胞遗传学的分析方法,对14例具有明显浆细胞分化特征的滤泡性淋巴瘤进行了研究。采用CD138抗体进行免疫组化染色以鉴定浆细胞,并且使用BCL-2、BCL-6、IGH和MALT1断裂探针以及12号染色体着丝粒探针对肿瘤中的浆细胞和淋巴细胞分别进行分析。这些探针
The authors used fluorescent immunophenotyping and interval cytogenetics to analyze 14 cases of follicular lymphoma with distinct plasma cell differentiation characteristics. Immunohistochemical staining with CD138 antibody was used to identify plasma cells and the plasma cells and lymphocytes in the tumor were analyzed separately using BCL-2, BCL-6, IGH and MALT1 cleavage probes and chromosome 12 centromere probe . These probes