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近年研究发现 ,以动脉粥样硬化 (ＡＳ)为主要病理改变的单纯收缩期高血压 (ＩＳＨ)患者血浆同型半胱氨酸 (Ｈｃｙ )水平明显增高〔1〕。Ｎ5 ,Ｎ10 亚甲基四氢叶酸还原酶(ＭＴＨＦＲ)基因Ｃ677Ｔ突变可能影响Ｈｃｙ代谢。我们旨在探讨ＭＴＨＦＲ基因Ｃ677Ｔ多态性与ＩＳＨ及其
In recent years, the study found that in patients with isolated systolic hypertension (ISH) with atherosclerosis (AS) as the main pathological changes in plasma homocysteine (Hcy) levels were significantly increased 〔1〕. N5, N10 methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation may affect Hcy metabolism. We aimed to investigate the MTHFR gene C677T polymorphism with ISH and its