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目的 :研究氟桂利嗪对青霉素致大鼠性发作和脑电活动的影响。方法 :用 60只Wistar大鼠分 4组 ,即对照组及氟桂利嗪10、2 0、40mg·kg-1组 ,2h后对照组和各实验组给同样剂量青毒素 3 0 0万U·kg-1腹腔注射 ,观察大鼠行为表现及EEG改变。结果 :氟桂利嗪能明显降低青霉素致大鼠性发作程度 ,明显缩短性发作持续时间 ,显著延长性发作的潜伏期 ,明显提高存活率 ;明显延长大脑皮质、海马性放电潜伏期 ,缩短其持续时间 ,明显减少性放电的数量。结论 :氟桂利嗪对青霉素致大鼠的性行为和大脑皮质、海马的性电活动均有抑制作用。
Objective: To investigate the effects of flunarizine on penicillata seizure and electroencephalogram in penicillin-induced rats. Methods: 60 Wistar rats were divided into 4 groups, namely control group and flunarizine 10, 20, 40 mg · kg-1 group. After 2 h, the control group and experimental groups were given the same dose of 0.3 million U · Kg-1 intraperitoneal injection to observe the behavioral performance and EEG changes. Flunarizine significantly reduced the degree of seizure in rats induced by penicillin, significantly shortened the duration of seizures, prolonged the latency of seizures, increased the survival rate obviously, prolonged the latency of sexual discharge in cerebral cortex and hippocampus , Shorten its duration, significantly reduce the number of sexual discharge. CONCLUSION: Flunarizine inhibits the nocturnal behaviors of penicillin-induced rats and the zonal electrical activities of cerebral cortex and hippocampus.