肝细胞肝癌是目前世界上发病率位居第五的恶性肿瘤,并有逐年上升的趋势。我们对进展期肝细胞肝癌已有很多的了解,但是对小肝癌的生物学特性还知之甚少,由于小肝癌诊断后大部分即通过各种介入手段进行治疗,因此我们得不到足够的肿瘤和非肿瘤标本进行研究。大部分手术切除的小肝 Hepatocellular carcinoma is the fifth highest incidence of malignant tumors in the world, and there is a trend of increasing year by year. We have a good understanding of advanced hepatocellular carcinoma, but little is known about the biological properties of small hepatocellular carcinoma. Since most of the diagnoses of small hepatocellular carcinoma are treated by various interventional modalities, we do not have enough tumors And non-tumor specimens were studied. Mostly resected small liver