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肿瘤细胞的多药耐药（multidrugresistance，MDR），系指对化学结构和作用机制不同的疏水性化合物的交叉耐药，是化疗失败的重要原因。在人，典型的MDR由MDRI基因产物P一糖蛋白（PPP）介导。近年免疫织化、核酸杂交以及序列分析的研究表明，P53基因与肿瘤化疗疗效及患者预后有
The multidrug resistance (MDR) of tumor cells refers to the cross-resistance of hydrophobic compounds with different chemical structures and mechanisms of action, which is an important cause of chemotherapy failure. In humans, a typical MDR is mediated by the MDRI gene product P-glycoprotein (PPP). In recent years, studies on immunohistochemistry, nucleic acid hybridization, and sequence analysis have shown that P53 gene and tumor chemotherapy efficacy and patient prognosis