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缬草油系宽叶缬草(Valeriana officinalis L.)的根经水蒸汽蒸馏精制而得的挥发油。据文献报道:缬草根有镇静安神、治疗神经衰弱、癔病等症的作用,与其中所含挥发油及倍半萜类成分有着密切关系。我院药理研究证明:缬草油有扩张血管、活血化瘀、改善微循环、防治肺脑水肿、心肌缺血损害、解除胃肠平滑肌痉挛及平喘等作用。但是,缬草油在水中溶解度较小,作成液体制剂较为困难。为了制成治疗上所需浓度的澄明溶液,增加缬草油的溶解度,是制剂中要解决的课题。为此,我们就吐温-80对缬草油的增溶作用及与缬草油的适当配比进行了探讨,现将结果报道如下。
The valerian oil is a volatile oil obtained by steam distillation of the root of Valeriana officinalis L. According to reports in the literature, valerian root has functions of sedation and tranquillity, treatment of neurasthenia and rickets, and has a close relationship with volatile oils and sesquiterpenoids contained therein. Our pharmacological studies have shown that valerian oil has the effects of dilating blood vessels, promoting blood circulation, reducing microcirculation, preventing and treating pulmonary brain edema, myocardial ischemic damage, and relieving gastrointestinal smooth muscle spasm and asthma. However, valerian oil is less soluble in water and it is more difficult to make a liquid formulation. In order to make a clear solution at the required concentration for treatment, increasing the solubility of valerian oil is a problem to be solved in the preparation. To this end, we discussed the solubilizing effect of Tween-80 on valerian oil and the proper ratio of valerian oil. The results are reported below.