本文用RE25-3食管癌细胞系研究了我国南方食管癌高发区鱼露的遗传毒性。鱼露浓度自16μl/ml到32μl/ml时,使细胞微核率增高1到3倍,且其作用随剂量增加而增强,同时鱼露还使细胞染色体数目增加。维甲酸、维胺酯及维胺酸对鱼露的毒性有拮抗作用,三者使微核率增高及染色体数日增加受抑制。 In this study, the genotoxicity of fish dew in high-risk area of ​​esophageal cancer in southern China was studied using RE25-3 esophageal cancer cell line. When the fish sauce concentration was from 16μl/ml to 32μl/ml, the micronucleus rate of the cells was increased by 1 to 3 times, and its effect was enhanced with the increase of the dose. At the same time, the fish sauce also increased the chromosome number of the cells. Retinoic acid, vitamide, and retinoic acid have antagonistic effects on the toxicity of fish sauce. Three of them increase the frequency of micronucleus and inhibit chromosome number increase.