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目的:建立测定复方磺胺甲噁唑片中磺胺甲噁唑和甲氧苄啶含量的简便方法。方法:采用一阶导数光谱法测定,磺胺甲噁唑的测定波长为258.8nm,甲氧苄啶的测定波长为238.2nm。结果:磺胺甲噁唑和甲氧苄啶的线性范围分别为5μgmL～50μgmL(r=0.9998),6μgmL～50μgmL(r=0.9996);平均回收率分别为99.6%,98.5%。结论:本法简便、准确,可用于复方磺胺甲噁唑片的质量控制。
Objective: To establish a simple method for the determination of sulfamethoxazole and trimethoprim in compound sulfamethoxazole tablets. Methods: The first-order derivative spectrophotometry was used to determine the sulfamethoxazole wavelength at 258.8 nm and the trimethoprim at 238.2 nm. Results: The linear ranges of sulfamethoxazole and trimethoprim were 5μgmL ~ 50μgmL (r = 0.9998) and 6μgmL ~ 50μgmL (r = 0.9996) respectively. The average recoveries were 99.6% and 98.5% respectively. Conclusion: This method is simple and accurate and can be used for quality control of compound sulfamethoxazole tablets.