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为了探索心脏外科手术时抗生素的安全有效的给药方案,作者对预防感染应用氰唑甲氧头孢菌素(Cefmetazole,简称CMZ)的临床病例进行血浓度、尿浓度和心肌浓度测定,分析CMZ的药物动力学.11例接受心肺分流手术病人,其中体外循环时间不满2小时者6例(A组),2小时以上者5例(B组),分别于麻醉导入后和进入外科加强护理单位(ICV)后1.5小时静脉注射CMZ 1g,收集血、尿和心肌样品,用
In order to explore a safe and effective dosing regimen of antibiotics during cardiac surgery, the authors tested the blood concentration, urinary concentration, and cardiac muscle concentration of clinical cases with Cefmetazole (CMZ) for the prevention of infection and analyzed the effects of CMZ Pharmacokinetics .11 patients undergoing cardiopulmonary bypass surgery, including 6 cases of cardiopulmonary bypass time less than 2 hours (group A), 5 cases of more than 2 hours (group B), respectively, after the introduction of anesthesia and into the surgical intensive care unit ICV) 1.5 hours after intravenous injection of CMZ 1g, collecting blood, urine and myocardial samples, with