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长春新碱(VT)引起神经毒性表现常见周围神经、自主神经功能障碍(便秘和尿潴留),而脑神经损害则少见。对近十年来接受VT治疗149例和有喉返神经麻痹163例进行调查,确定属VT引起的喉返神经麻痹致声带麻痹(VCP)3例,可疑1例。本组2例双侧VCP,1例为单侧,停药后均自行恢复。VT引起脑神经损害最多发生喉和眼外肌受累,第X脑神经损害表现声嘶、发声无力、哮鸣、发绀和误吸。脑神经侵犯少见且在围围神经和自主神经受损后发生。通常调整VT剂量或停药后4～6周症状可缓慢消失。在60年代临床应
Vincristine (VT) causes neurotoxicity that manifests itself mostly in peripheral nerves and autonomic dysfunction (constipation and urinary retention), whereas cranial nerve damage is rare. In the past ten years, 149 cases were treated with VT and 163 cases with recurrent laryngeal nerve paralysis were investigated to determine the VT caused by recurrent laryngeal nerve paralysis caused vocal cord paralysis (VCP) in 3 cases, 1 case of suspicious. The two cases of bilateral VCP, 1 case of unilateral, self-recovery after withdrawal. VT caused the most damage to the brain and throat and extraocular muscle involvement, the performance of the first cerebral cranial nerve hoarseness, vocal weakness, wheezing, cyanosis and aspiration. Invasive cranial nerve infrequent and occurred in the peripheral nerve and autonomic nerve damage occurred. Usually adjust the dose of VT or withdrawal 4 to 6 weeks after the symptoms can slowly disappear. In the 60’s clinical should