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目的:探讨分析血清胃蛋白酶原检测对消化性溃疡的临床诊断价值。方法:选取我院2013年1月-2013年12月间收治的60例经胃镜检查明确诊断确诊为消化性溃疡的患者作为观察组,另选取同期60例来院进行健康体检的健康志愿者作为对照组,采用TRFIA(时间分辨荧光免疫分析法)对观察组患者和对照组健康志愿者血清胃蛋白酶原的含量进行检测和对比,分析血清胃蛋白酶原检测对消化性溃疡的临床诊断价值。结果:观察组患者的胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ明显高于对照组健康志愿者,P<0.05具有显著性差异,有统计学意义;观察组患者的胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ的比值明显低于对照组健康志愿者,P<0.05具有显著性差异,有统计学意义。结论:血清胃蛋白酶原上升是消化性溃疡发生的一个危险因素,是消化性溃疡临床诊断和疗效评价的重要血清学指标,血清胃蛋白酶原检测对消化性溃疡的临床诊断价值较高,具有重要的指导意义。
Objective: To investigate the clinical diagnostic value of serum pepsinogen test on peptic ulcer. Methods: Sixty patients diagnosed as peptic ulcer by gastroscopy were selected as the observation group from January 2013 to December 2013 in our hospital. Another 60 healthy volunteers who were hospitalized for physical examination during the same period were selected as the control group Group, TRFIA (time-resolved fluorescence immunoassay) was used to detect and compare the levels of serum pepsinogen in observation group patients and control healthy volunteers, and to analyze the clinical value of serum pepsinogen test in the diagnosis of peptic ulcer. Results: The levels of pepsinogen Ⅰ and pepsinogen Ⅱ in observation group were significantly higher than those in healthy volunteers in control group (P <0.05). There was significant difference between the two groups (P <0.05). The levels of pepsinogen Ⅰ / pepsinogen Ⅱ The ratio was significantly lower than the control group of healthy volunteers, P <0.05 with significant differences, with statistical significance. Conclusion: The increase of serum pepsinogen is a risk factor of peptic ulcer, and it is an important serological indicator of clinical diagnosis and curative effect evaluation of peptic ulcer. Serum pepsinogen detection is of high value in the clinical diagnosis of peptic ulcer and is important The guiding significance.