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据报道食管癌与饮用烫热的饮料尤其是热茶有明显的关系。本文作者曾证明狗和人的食管有一道防御氢离子的“粘膜屏障”,但当胆盐、酒精、阿司匹林和胃蛋白酶存在时,氢离子便较易通过这一屏障(Surg Forum 25:335,1974)。本研究试图在将狗的食管远端阻塞后确定冷、热茶对离子通过粘膜的数量的影响。结果:滴入每升含100毫当量的盐酸溶液100毫升后,每30分钟氢离子平均净损失为0.21±0.08毫当量/升,如在溶液中加入1包茶叶后,氢离子的损失便增至1.47±0.38毫当量/升(P<0.01),当使用已加入1包茶叶的热盐酸溶液(温度60℃)时,则氢离子的损失更为明显,增至2.40±0.42毫当量/升(P<0.001)。
It is reported that esophageal cancer and drinking hot drinks, especially hot tea has a clear relationship. The authors of this article have shown that dogs and humans have a “mucosal barrier” to the esophagus that prevents hydrogen ions from passing through the barrier when hydrogen chloride is present in bile salts, alcohol, aspirin, and pepsin (Surg Forum 25: 335, 1974). This study sought to determine the effect of cold and hot tea on the amount of ions passing through the mucosa after obstruction of the distal end of the esophagus in dogs. Results: The average net loss of hydrogen ions was 0.21 ± 0.08 meq / L every 30 minutes after instilling 100 ml of hydrochloric acid solution containing 100 milliliters per liter. As one pack of tea leaves was added to the solution, the loss of hydrogen ions was increased To 1.47 ± 0.38 meq / L (P <0.01). The hydrogen ion loss was even more pronounced to 2.40 ± 0.42 meq / L when hot hydrochloric acid solution (temperature 60 ° C) (P <0.001).