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目的:考察氨茶碱注射液与注射用甲泼尼龙琥珀酸钠的配伍稳定性。方法:观察及测定2种注射剂在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温放置8h内的外观、pH及不溶性微粒,并采用高效液相色谱法测定配伍液中主药的含量。结果:室温8h内,氨茶碱与甲泼尼龙琥珀酸钠在0.9%氯化钠注射液和5%葡萄糖注射液中的外观、pH均无明显变化,但配伍液的微粒数不断减少,甲泼尼龙琥珀酸钠的含量变化明显。结论:氨茶碱与甲泼尼龙琥珀酸钠不宜在0.9%氯化钠注射液和5%葡萄糖注射液中配伍。
Objective: To investigate the compatibility of aminophylline injection with methylprednisolone sodium succinate. Methods: To observe and measure the appearance, pH and insoluble particles of the two injections in 0.9% sodium chloride injection and 5% dextrose injection at room temperature for 8 hours. The contents of main components Drug content. Results: The appearance and pH of aminophylline and methylprednisolone sodium succinate in 0.9% sodium chloride injection and 5% glucose injection did not change significantly within 8 hours at room temperature, but the number of particles in the compatibility solution decreased continuously. The content of prednisolone sodium succinate changed significantly. Conclusion: Aminophylline and methylprednisolone sodium succinate should not be compatible with 0.9% sodium chloride injection and 5% glucose injection.