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目的：评价犬烟雾吸入性损伤吸入一氧化氮（ＮＯ）肺脏病理改变与肺组织能量代谢的变化。方法：２１只犬随机分为３组，烟雾吸入损伤后，对照组（ｎ＝８）单纯吸氧（ＦｉＯ２，０．４５），治疗组（ｎ＝９）吸氧（ＦｉＯ２，０．０４５）＋０．００４５％（４５ｐｐｍ）ＮＯ，正常组（ｎ＝４）不致伤，用于建立病理和组织学对照。实验终点进行肺组织学和病理形态学检测。结果：对照组ＡＴＰ含量和能量负荷（ＥＣ）显著低于正常和治疗组（Ｐ＜０．０１），ＡＤＰ和ＡＭＰ含量明显低于正常组（Ｐ＜０．０５），而与治疗组相比无显著差别（Ｐ＞０．０５）；肺脏光镜和电镜病理所见，治疗组病理性改变程度较对照组轻。结论：在烟雾吸入性损伤犬模型中，吸入ＮＯ可不同程度改善肺组织能量代谢，肺脏病理形态改变也有一定程度减轻，表明治疗方法有一定效果
Objective: To evaluate the change of pulmonary pathological changes and energy metabolism of inhaled nitric oxide (NO) inhalation injury in dogs. Methods: Twenty-one dogs were randomly divided into three groups. After smoke inhalation injury, FiO2 (0.45) in the control group (n = 8) and FiO2 (0.045) in the treatment group + 0.0045% (45ppm) NO, normal group (n = 4) non-injury, for the establishment of pathological and histological control. End of the experiment lung histology and pathological examination. Results: The ATP content and energy load (EC) of the control group were significantly lower than those of the normal group and the untreated group (P <0.01), while the levels of ADP and AMP were significantly lower than those of the normal group (P <0.05) No significant difference (P> 0.05); lung light and electron microscopy pathology, the treatment group pathological changes than the control group light. Conclusion: In inhalation injury model of canines, NO inhalation can improve the energy metabolism of lung tissue to varying degrees, and the pathological changes of lung have also been alleviated to a certain degree, indicating that the treatment has some effects