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目的探讨前列灵胶囊对慢性前列腺炎(Chronic prostatitis,CP)大鼠前列腺BAX蛋白、BCL-2蛋白表达的影响。方法以60只SPF级SD大鼠为观察对象,消痔灵注射液进行前列腺内注射制作CP模型,以前列灵胶囊高、中、低剂量以及前列通瘀胶囊灌胃作为干预方法,观察大鼠前列腺组织中凋亡因子BAX、BCL-2蛋白表达变化。结果前列通瘀、前列灵胶囊高剂量能使CP大鼠前列腺组织中促进凋亡因子BAX蛋白表达减少(P<0.05),抑制凋亡因子BCL-2蛋白表达增加(P<0.05)。结论细胞凋亡因子BAX、BCL-2与CP密切相关,前列灵胶囊能通过调节细胞凋亡情况而改善前列腺炎症反应。
Objective To investigate the effect of Qianlieling capsule on the expression of BAX protein and BCL-2 protein in prostate of chronic prostatitis (CP) rats. Methods Sixty Sprague-Dawley rats were used as observation objects. The model of CP was established by intraperitoneal injection of Xiaozhiling injection. The high, medium and low doses of Qianlieling capsules and the intragastric administration of Qianlietongyu capsule were used as interventions. Prostate tissue apoptosis factor BAX, BCL-2 protein expression changes. Results Qianlietongyu and Qianlieling capsule could inhibit the expression of BAX protein (P <0.05) and inhibit the expression of BCL-2 protein (P <0.05) in the prostatic tissue of CP rats. Conclusions Apoptosis factors BAX and BCL-2 are closely related to CP. Qianlieling capsule can improve prostatic inflammatory response through regulating apoptosis.