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目的检测UmALB、血清CysC、Cr和BUN水平的变化,探讨几者联合检测在GDM早期肾损伤中的诊断价值。方法选择GDM患者104例,按孕周分为GDM中妊组、GDM晚妊组;正常妊娠组82例,分为正常中妊组、正常晚妊组;同期健康体检者90例,作为正常对照组。采用速率散射比浊法测定UmALB,免疫透射比浊法测CysC,已糖激酶法测血糖,脲酶法测定BUN,采用酶法测定Cr。结果 GDM中妊组、GDM晚妊组与正常对照组比较,GDM中妊组与正常中妊组比较,GDM晚妊组与正常晚妊组比较,GDM晚妊组与GDM中妊组比较,上述指标的水平明显升高;GDM组与正常对照组和正常妊娠组比较,上述指标的阳性率均明显升高;相关性分析结果表明,UmALB和血清CysC、Cr和BUN水平均呈正相关。结论上述指标是监测GDM早期肾损伤灵敏又可靠的指标;联合检测几者对GDM早期肾损伤具有重要诊断价值。
Objective To detect the changes of UmALB, serum CysC, Cr and BUN levels, and to explore the diagnostic value of the combined detection of these drugs in the early stage of GDM nephropathy. Methods Totally 104 GDM patients were divided into GDM pregnancy group and GDM late pregnancy group according to gestational age. Normal pregnancy group (n = 82) was divided into normal pregnancy group and normal late pregnancy group. 90 healthy subjects were selected as normal control group group. UmALB was determined by rate nephelometry, CysC by immunoturbidimetric assay, blood glucose was measured by glycoderase method, BUN was determined by urease method, and Cr was determined by enzymatic method. Results GDM late pregnancy group and GDM late pregnancy group compared with the normal control group, GDM pregnancy group compared with the normal pregnancy group, GDM late pregnancy group compared with normal late pregnancy group, GDM late pregnancy group and GDM pregnancy group, the above The positive rate of the above indexes was significantly higher in GDM group than in normal control group and normal pregnancy group. Correlation analysis showed that UmALB and serum CysC, Cr and BUN levels were positively correlated. Conclusion The above indexes are sensitive and reliable indicators for monitoring early renal injury in GDM. Combined detection of these indexes is of great diagnostic value for early renal injury of GDM.