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本研究探讨了帕金森病(Parkinson’s disease,PD)患者丘脑底核(subthalamic nucleus,STN)神经元电活动的特点及其与PD症状的关系。35例PD患者在接受手术治疗的同时,应用微电极细胞记录和EMG记录技术,记录手术靶点STN及其周围结构神经元的电活动以及手术对侧肢体的EMG。应用分析软件甄别单细胞电活动,分析其特点及其与肢体EMG的关系。结果表明,STN及其周围结构具有特征性放电活动。在36个记录针道中,共发现436个STN神经元,平均放电频率44.0±20.5 Hz。其中,56%的神经元呈不规则簇状放电;15%呈紧张性放电;29%呈规则的簇状放电,其放电节律与肢体震颤的EMG高度一致(r~2=0.66,P<0.01),称之为震颤细胞。在PD震颤型患者的STN中发现大量震颤细胞,且80%位于STN中上部,而在PD僵直型患者的STN中均发现与运动相关的细胞电活动。本研究提示,通过微电极记录技术可准确地判断STN的位置和范围;与震颤活动相关的细胞放电和与运动相关细胞的放电与PD症状有内在关系;STN参与PD运动障碍的病理生理过程。
This study investigated the characteristics of electrical activity of subthalamic nucleus (STN) neurons in Parkinson’s disease (PD) and their relationship with PD. 35 cases of PD patients undergoing surgical treatment at the same time, the use of microelectrode cell recording and EMG recording technology, record the electrical activity of the surgical target STN and its surrounding structural neurons and the contralateral limb EMG. Application software analysis of single cell activity screening, analysis of its characteristics and limb EMG relationship. The results show that STN and its surrounding structures have characteristic discharge activity. A total of 436 STN neurons were found in 36 recording tracks with an average discharge frequency of 44.0 ± 20.5 Hz. Among them, 56% of the neurons showed irregular cluster discharges; 15% developed tension discharges; and 29% showed regular cluster discharges. Their firing rhythms were highly consistent with limb tremor EMG (r ~ 2 = 0.66, P <0.01) ), Called tremor cells. A large number of tremor cells were found in the STN of patients with PD tremor and 80% were located in the upper part of the STN, whereas motor activity-related cellular electrical activity was found in STN of patients with PD skeletal muscle. This study suggests that the location and extent of STN can be accurately judged by the microelectrode recording technique. There is an internal relationship between tremor-related cell discharge and exercise-related cell discharge and PD symptoms. STN is involved in the pathophysiology of PD dyskinesia.