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目的观察三养胶麦食疗辅助治疗超重和肥胖2型糖尿病(T2DM)患者的临床疗效。方法将体重指数(BMI)≥25kg·m-2的120例T2DM患者,随机分为三养胶麦食疗组(A组)和普通糖尿病饮食组(B组)两组,在口服降血糖药物治疗的前提下,两组T2DM患者于治疗前后(0周,12周)测量患者的血压(BP)、体重并计算体重下降净值和下降百分数、空腹血糖、空腹胰岛素、糖基化血红蛋白(HbA1c)、血脂谱和血尿酸、r-谷氨酰转肽酶(GGT)和用药情况。结果 A组的体重、BP、口服降血糖药物用量明显低于B组(P<0.05),停药率明显高于B组(P<0.01);而且糖、脂蛋白和尿酸代谢的改善程度明显优于B组(P<0.05);空腹胰岛素和GGT也明显低于B组(P<0.05)。结论三养胶麦食疗可降低超重和肥胖T2DM患者的体重,有助于代谢综合征的改善,并可减少口服降血糖药物用量。
Objective To observe the clinical efficacy of San Yang Gum Wheat in the treatment of overweight and obese type 2 diabetes mellitus (T2DM) patients. Methods A total of 120 T2DM patients with body mass index (BMI) ≥25kg · m-2 were randomly divided into three groups: the control group (group A) and ordinary diabetic diet group (group B) (BP) and body weight were measured before and after treatment (0 week, 12 weeks) in two groups of T2DM patients, and the net and the percentage of body weight loss, fasting blood glucose, fasting insulin, glycosylated hemoglobin (HbA1c) Blood lipid profile and serum uric acid, r-glutamyl transpeptidase (GGT) and medication. Results The body weight, BP and oral hypoglycemic drugs in group A were significantly lower than those in group B (P <0.05), and the withdrawal rates were significantly higher in group A than those in group B (P <0.01). And the improvement of glucose, lipoprotein and uric acid metabolism was obvious (P <0.05). Fasting insulin and GGT were also significantly lower than those in group B (P <0.05). Conclusion San Yang Ging Mai diet can reduce overweight and obese T2DM patients with body weight, contribute to the improvement of metabolic syndrome, and reduce the amount of oral hypoglycemic agents.