论文部分内容阅读
为观察守宫水蛭组方是否对大鼠局灶性脑缺血再灌注损伤有保护作用 ,将 4 8只Wester大鼠随机分为偏瘫康大、小剂量组、模型组、假手术组、西比灵及华佗再造丸阳性对照组 ,分别给予一周药物后用尼龙线栓塞大脑中动脉 ,栓塞 1h后再通 ,制做局部脑缺血再灌注损伤模型 ,于手术后分别对大鼠行为障碍进行术后评分 ,断脑取血测血清乳酸脱氢酶和肌酸激酶含量 ,取手术侧脑测定含水量及脑组织Na+ 、K+ 、Ca2 + 和Mg2 + 含量。结果发现 ,脑缺血再灌注损伤 6h后 ,大鼠行为障碍术后评分增高 ,出现脑水肿 ,Na+ 含量增高 ,血清乳酸脱氢酶和肌酸激酶含量也明显升高 ;而预先服用不同剂量的守宫水蛭组方均可明显逆转大鼠脑缺血再灌注损伤的上述变化。说明守宫水蛭组方对大鼠局灶性脑缺血再灌注损伤有保护作用
To observe whether the protective effect of GSHHYF has a protective effect on focal cerebral ischemia-reperfusion injury in rats, forty-eight Wester rats were randomly divided into two groups: hemiplegia, low dose group, model group, sham operation group, and western Piling and Huatuo Zaizao Pills positive control group were given one week’s drug and then the middle cerebral artery was embolized with nylon thread and then embolized for one hour. The model was established as a model of focal cerebral ischemia-reperfusion injury. Postoperative scores were taken to measure blood serum lactate dehydrogenase and creatine kinase levels. The lateral brain was used to determine the water content and Na+, K+, Ca2+, and Mg2+ levels in the brain. The results showed that after 6 hours of cerebral ischemia-reperfusion injury, scores of behavioral disorders in rats increased, brain edema appeared, Na+ content increased, serum lactate dehydrogenase and creatine kinase levels also increased significantly, while pre-administration of different doses Both of the prescriptions of Gongshui Shuizhe significantly reversed the above changes in cerebral ischemia-reperfusion injury in rats. It is shown that the prescription of “Shou Gong Shui Qun” has protective effect on focal cerebral ischemia-reperfusion injury in rats