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激活的血小板间的互相粘附以及粘附于血管壁是血栓和止血研究的中心问题。对这一过程早期的研究表明,粘附蛋白如纤维蛋白原(Fg),von Willebrand因子(vWF)在这些过程中具有重要作用。由于已进一步了解这些过程的分子细节,因此,目前已经清楚,血小板的粘附反应与其他细胞类型的粘附具有明显相似性。而且,似乎参与这些反应的3个血小板受体是广泛分布的粘附受体总科(Superfamily)成员。确认这种粘附受体总科的存在,对血小板领域的工作者提出了新颖的研究方向。一.血小板粘附受体与其他细胞类型粘附受体具有同一识别特性血小板粘附机制概念早期来自确定粘附蛋白内特异性识别位点的研究。纤维连接蛋白(Fn)是多种
The mutual adhesion of activated platelets and adhesion to the blood vessel wall are central issues in thrombotic and hemostasis studies. Earlier research on this process showed that adhesion proteins such as fibrinogen (Fg) and von Willebrand factor (vWF) play an important role in these processes. As the molecular details of these processes have been further understood, it is now clear that the platelet adhesion response is clearly similar to that of other cell types. Moreover, the three platelet receptors that appear to be involved in these responses are members of the widely distributed family of Adhesion receptors (Superfamily). Confirming the existence of this adhesion receptor superfamily, put forward a novel research direction for workers in the field of platelets. I. Platelet Adhesion Receptors have the same recognition characteristics as Adhesion Receptors of other cell types. Platelet Adhesion Mechanism Concept The early stage of the study was to determine the specific recognition sites within the adhesion proteins. Fibronectin (Fn) is a variety of