论文部分内容阅读
目的:探讨采用Vitapex糊剂治疗慢性根尖周炎的效果及对血清肿瘤坏死因子α(TNF-α)、C反应蛋白和白细胞介素6影响。方法:选择杭州市大江东医院于2018年1月至2019年6月收治的慢性根尖周炎患者120例，依据随机数字表法分为观察组60例与对照组60例。观察组患者采用Vitapex糊剂治疗，对照组患者采用氢氧化钙糊剂治疗。比较两组术后7 d疼痛情况，术前和术后7 d血清TNF-α、C反应蛋白和白细胞介素6变化，术前和术后6个月根管菌落数变化，及术后6个月疗效情况。结果:观察组术后7 d无疼痛或轻度疼痛(30.00%)多于对照组(10.00%)(χn 2＝7.500，n P<0.05)；观察组术后7 d血清TNF-α(4.68±1.20)μg/L、C反应蛋白(4.35±0.79)mg/L、白细胞介素6(2.15±0.54)μg/L，均低于对照组的(7.89±1.42)μg/L、(8.19±1.32)mg/L和(4.58±1.02)μg/L(n t＝13.472、19.335、16.309，均n P<0.05)；观察组术后6个月根管菌落数(4.26±0.35)CFU，少于对照组的(9.72±2.43)CFU(n t＝17.227，n P<0.05)；观察组总有效率(90.00%)高于对照组(73.33%)(χn 2＝5.566，n P<0.05)。n 结论:Vitapex糊剂对慢性根尖周炎患者效果明显，且可降低血清TNF-α、C反应蛋白和白细胞介素6水平。“,”Objective:To investigate the effect of Vitapex paste on chronic periapical periodontitis and its influence on serum TNF-α, C-reactive protein(CRP) and IL-6.Methods:From January 2018 to June 2019, 120 patients with chronic periapical periodontitis admitted to Dajiangdong Hospital in Hangzhou were randomly divided into observation group (60 cases) and control group (60 cases) according to the random digital table method.The patients in the observation group were treated with Vitapex paste, while the patients in the control group were treated with calcium hydroxide paste.The changes of serum TNF-α, CRP and IL-6, the changes of the number of bacterial colonies in the root canal before and 6 months after operation, and the therapeutic effect at 6 months after operation were compared.Results:The patients with no pain or mild pain in the observation group at 7 days after operation (30.00%) was more than that in the control group (10.00%) (χn 2=7.500, n P<0.05). The levels of TNF-α [(4.68±1.20)μg/L], CRP [(4.35±0.79)mg/L] and IL-6 [(2.15±0.54)μg/L] in the observation group were lower than those in the control group [(7.89±1.42)μg/L, (8.19±1.32)mg/L and (4.58±1.02)μg/L] (n t=13.472, 19.335 and 16.309, all n P<0.05). At 6 months after operation, the number of bacterial colonies in the root canal of the observation group [(4.26±0.35)CFU] was lower than that of the control group [(9.72±2.43)CFU](n t=17.227, n P<0.05). The total effective rate of the observation group (90.00%) was higher than that of the control group (73.33%) (χn 2=5.566, n P<0.05).n Conclusion:Vitapex paste is effective in the treatment of chronic periapical periodontitis, and can reduce the serum levels of TNF-α, CRP and IL-6.