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黄连解毒汤提取物(TJ-15)能防止肥大细胞脱粒剂(化合物48/80)所致的大鼠急性胃粘膜损害。水浸拘束(WIR)应激模型大鼠胃粘膜组织中氧自由基的产生及脂质过氧化和巯基氧化是急性胃粘膜损害的主要病理过程。TL-15对WIR应激造成的急性胃粘膜损害是否有保护作用尚存争议,至今尚无有关动物实验的报道。此外,柴胡桂枝汤提取物(TJ-10)和四逆散提取物(TJ-35)不仅能清除氧自由基,还对缺血-再灌注造
Huanglianjiedutang extract (TJ-15) can prevent acute gastric mucosal damage caused by mast cell degranulation (compound 48/80) in rats. The production of oxygen free radicals, lipid peroxidation and sulfhydryl oxidation in the gastric mucosa of rats with water-immersion (WIR) stress are the main pathological processes of acute gastric mucosal lesions. Whether TL-15 has a protective effect on acute gastric mucosal damage caused by WIR stress is still controversial. There have been no reports of animal experiments. In addition, Chaihu Guizhi Decoction (TJ-10) and Sinisan Extract (TJ-35) not only can scavenge oxygen free radicals but also to ischemia-reperfusion injury.