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目的 :利用标记免疫分析CA5 0 ,CA12 5 ,CA199和CA15 3水平进行肝癌、结直肠癌、卵巢癌、胰腺癌、乳腺癌、肺癌和胃癌的诊断研究。方法 :标记免疫分析了 6 7例肝癌 ,88例结直肠癌 ,48例卵巢癌 ,36例胰腺癌、乳腺癌 ,12 8例肺癌 ,2 71例胃癌和 6 8例正常对照组。CA5 0 ,CA12 5 ,CA199和CA15 3的批内变异分别为3 7% ,4 8% ,7 6 %和 8 1% ,批间变异分别为 8 1% ,10 1% ,12 3%和 10 4% ,回收率平均介于 95 %～ 10 7%之间。结果 :6 7例肝癌CA5 0 ,CA12 5 ,CA199和CA15 3分别为 40 1± 30 0U/ml,2 8 1± 2 1 2U/ml,11 4± 9 6U/ml和16 2± 8 0U/ml;88例结直肠癌分别为 6 7 8± 45 0U/ml,44 4± 36 1U/ml,6 0 1± 35 8U/m和 2 0 8± 14 8U/ml;48例卵巢癌分别为 40 6± 2 5 1U/ml,180 1± 10 0 2U/ml,15 1± 11 2U/ml和 47 1± 16 4U/ml;36例胰腺癌分别为37 1± 2 2 1U/ml,2 1 8± 14 2U/ml,2 34 2± 6 6 5U/ml和 17 1± 9 1U/ml;34例乳腺癌分别为 10 4± 4 4U/ml,16 4± 9 8U/ml,11 8± 9 8U/ml和 80 1± 36 3U/ml;12 8例肺癌分别为 13 0± 4 6U/ml,10 0 1± 76 4U/ml,12 1±8 8U/ml和 40 3± 18 1U/ml;2 71例胃癌分别为 6 0 6± 40 1U/ml,2 5 7± 18 1U/ml,80 3± 43 2U/ml?
OBJECTIVE: To study the diagnosis of liver cancer, colorectal cancer, ovarian cancer, pancreatic cancer, breast cancer, lung cancer and gastric cancer by using labeled immunoassay of CA5 0, CA12 5, CA199 and CA15 3. Methods: Sixty-seven cases of liver cancer, 88 cases of colorectal cancer, 48 cases of ovarian cancer, 36 cases of pancreatic cancer, breast cancer, 12 8 cases of lung cancer, 2171 cases of gastric cancer and 68 cases of normal controls were labeled immunoassay. The intra-assay variations of CA5 0, CA12 5, CA199 and CA15 3 were 37%, 48%, 76% and 81%, respectively, with inter-assay variation of 81%, 101%, 123% and 10% 4%, the average recoveries ranged from 95% to 107%. Results: The mean tumor markers of CA5 0, CA12 5, CA199 and CA15 3 were 40 1 ± 30 0U / ml, 281 ± 21 2U / ml, 11 4 ± 96U / ml and 16 2 ± 80U / ml; 88 cases of colorectal cancer were 6 7 8 ± 45 0U / ml, 44 4 ± 36 1U / ml, 6 0 1 ± 35 8U / m and 2 0 8 ± 14 8U / ml; 48 cases of ovarian cancer were 40 6 ± 2 5 1U / ml, 180 1 ± 10 0 2U / ml, 15 1 ± 11 2U / ml and 47 1 ± 16 4U / ml; 36 cases of pancreatic cancer were 37 1 ± 2 2 1U / ml, 2 1 8 ± 14 2U / ml, 2 34 2 ± 6 6 5U / ml and 17 1 ± 9 1U / ml, 34 cases of breast cancer were 104 ± 4 4U / ml, 16 4 ± 9 8U / ml and 118 ± 8 8U / ml and 80 1 ± 36 3U / ml; 12 8 cases of lung cancer were 13 0 ± 4 6U / ml, 1001 ± 76 4U / ml, 12 1 ± 8 8U / ml and 40 3 ± 18 1U / ml; 2 71 cases of gastric cancer were 6 0 6 ± 40 1U / ml, 257 ± 18 1U / ml, 80 3 ± 43 2U / ml?