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目的:探讨液基薄层细胞学检查(TCT)联合DNA倍体细胞检测在普查宫颈疾病中的临床价值。方法:分析2010年5月-2011年5月在我院妇女保健科完成宫颈TCT联合DNA倍体细胞检测的已婚妇女6 747例,对347例宫颈TCT检查阳性患者及262例DNA倍体细胞检测阳性(扫描结果3个以上>5C非整倍体细胞)患者行阴道镜检查,依据病理结果分析符合率。结果:未明确意义的不典型鳞状细胞(AS-CUS)177例,低度鳞状上皮内病变(L-SIL)106例,高度鳞状上皮内病变(H-SIL)64例,同时接受DNA倍体细胞检测阳性率分别为61.0%,84.9%,100%。AS-CUS组的DNA倍体细胞检测阳性率与L-SIL、H-SIL之间的差异有统计学意义(P<0.05)。TCT阳性347人,病理学检查(病检)阳性74人,符合率21.3%,TCT及DNA倍体细胞检测均阳性262人,病检阳性92人,阳性符合率35.1%。两组与病检符合率比较,差异有统计学意义(P<0.05)。且随着病理级别升高,TCT及DNA倍体细胞均阳性检出率也越来越高。结论:宫颈TCT检测联合DNA倍体细胞检测,能有效提高宫颈疾病的检出率,结合病理检查,可早期发现宫颈癌前病变,是普查宫颈疾病的可靠方法。
Objective: To investigate the clinical value of liquid-based thin-layer cytology (TCT) combined with DNA ploidy detection in screening cervical diseases. Methods: From June 2010 to May 2011, 6 747 married women with cervical TCT combined with DNA ploidy test were screened in the women's health department of our hospital from May 2010 to May 2011. 347 cervical TCT positive patients and 262 DNA ploidy cells Patients with positive results (more than 3 scans> 5C aneuploidy) underwent colposcopy, and the coincidence rate was analyzed according to the pathological results. Results: There were 177 cases of atypical squamous cell (AS-CUS), 106 cases of low grade squamous intraepithelial lesion (L-SIL) and 64 cases of high grade squamous intraepithelial lesion (H-SIL) DNA ploidy test positive rates were 61.0%, 84.9%, 100%. The positive rate of DNA ploidy in AS-CUS group was significantly different from that of L-SIL and H-SIL (P <0.05). TCT positive 347, pathological examination (pathological) positive 74, with a coincidence rate of 21.3%, TCT and DNA ploidy cells were detected in 262 positive, pathologically positive 92, the positive coincidence rate of 35.1%. The coincidence rate of the two groups and the pathological examination showed a significant difference (P <0.05). And with the pathological level increased, TCT and DNA ploidy cells are also higher positive detection rate. Conclusion: Cervical TCT combined with DNA ploidy detection can effectively improve the detection rate of cervical disease, combined with pathological examination, early detection of cervical precancerous lesions is a reliable method for screening cervical disease.