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目的探讨691例江苏省南京市及镇江市女性外阴尖锐湿疣(CA)组织中人乳头瘤病毒(HPV)感染基因型分布状态和分型的临床意义。方法采用基因扩增结合基因芯片技术对江苏省南京市665例及镇江市26例女性外阴尖锐湿疣组织标本进行23种HPV分型检测,并对患者的相关资料进行分析。结果 691例女性外阴尖锐湿疣患者检出HPV感染者597例,总HPV感染率为86.40%(597/691),其中一型感染率为51.38%(355/691),以11、6和16型最为常见,分别占一型感染51.55%(183/355)、41.97%(149/355)和3.38%(12/355)。多型感染率为35.02%(242/691),以6+11型、11+18型、6+16型和11+16型为主,其分别占多型感染9.92%(24/242)、9.09%(22/242)、4.96%(12/242)和4.13%(10/242)。结论南京市及镇江市女性外阴CA组织中HPV感染,以低危型感染为主,高危型感染为辅,行外阴CAHPV分型检测,对我国女性外阴CA和宫颈病变的防治具有十分重要的意义。
Objective To investigate the clinical significance of genotype distribution and typing of human papillomavirus (HPV) infection in 691 cases of vulva condyloma acuminatum (CA) in Nanjing and Zhenjiang of Jiangsu Province. Methods Twenty-three types of HPV genotypes were detected in 665 cases of female genital condyloma acuminatum in 665 Nanjing, Jiangsu Provinces and in Zhenjiang City by gene amplification and gene chip technology. The related data of the patients were analyzed. Results A total of 597 cases of HPV infection were detected in 691 cases of female genital warts. The total HPV infection rate was 86.40% (597/691). The infection rate of type 1 was 51.38% (355/691) The most common type I infections were 51.55% (183/355), 41.97% (149/355) and 3.38% (12/355), respectively. The prevalence of polytype infection was 35.02% (242/691), mainly 6 + 11, 11 + 18, 6 + 16 and 11 + 16, which accounted for 9.92% (24/242) 9.09% (22/242), 4.96% (12/242) and 4.13% (10/242). Conclusions HPV infection in female genital CA tissue in Nanjing and Zhenjiang City is mainly low-risk type and supplemented by high-risk type. Detection of genital CAHPV typing is of great significance to the prevention and treatment of female genital CA and cervical lesions in China .