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目的:观察胰岛素泵持续性皮下胰岛素输注(CSII)治疗前后胰岛β细胞第一时相胰岛素分泌的变化。方法:将新诊断的2型糖尿病患者20例治疗前后均进行静脉葡萄糖耐量试验(IVGTT),测定血糖及0、1、3、5、10 min血浆胰岛素,比较各组患者治疗前后胰岛β细胞第一时相胰岛素功能变化情况。结果:治疗后血糖水平明显下降,各点血浆胰岛素均明显升高(P<0.01)。结论:胰岛素泵强化治疗可改善新诊断2型糖尿病患者的胰岛β细胞第1时相胰岛素分泌。
Objective: To observe the change of first phase insulin secretion of pancreatic β cells before and after continuous subcutaneous insulin infusion (CSII) with insulin pump. Methods: Twenty patients with newly diagnosed type 2 diabetes mellitus were treated with intravenous glucose tolerance test (IVGTT) before and after treatment. Blood glucose and serum insulin at 0, 1, 3, 5 and 10 min were measured. Before and after treatment, Temporal changes in insulin function. Results: After treatment, the level of blood glucose decreased significantly, and the level of plasma insulin increased significantly (P <0.01). Conclusion: Intensive insulin pump therapy can improve the first phase insulin secretion of pancreatic β cells in newly diagnosed type 2 diabetic patients.