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患者,男,19岁.因头昏、乏力4年余,于1982年在我院门诊首次就医发现脾大平脐.Hb78g/l,WBC72×10~9/l,分类:早幼粒0.01、中幼粒0.21、晚幼粒0.24、杆状粒0.22、分叶粒0.23、嗜碱粒0.08,血小板(BPC)51×10~9/l.骨髓象:原粒0.02,早幼粒0.03、中幼粒0.23,晚幼粒0.27,分叶0.34,诊断为慢性粒细胞白血病(慢粒).给马利兰治疗后症状缓解,脾脏明显回缩出院.于1985年10月初,又感乏力、头昏,出现骨痛半月余,住院用马利兰治疗无效,改用1,2:5,6二去水乙茅醇(DAG)治疗后,症状缓解出院.因发热、骨痛、腹胀,皮肤粘膜出血点1周,于1986年7月21日再次到本院就诊,以“慢粒急变”收住.
Patient, male, 19 years old. He was dizziness and fatigued for more than 4 years. He was found in our hospital for the first time in 1982. He was found to have spleen and umbilicus. Hb78g/l, WBC72×10~9/l, Classification: 0.01, medium Pellet 0.21, late young grain 0.24, rod-shaped grain 0.22, sub-leaf grain 0.23, basophilic grain 0.08, platelet (BPC) 51×10~9/l. bone marrow elephant: raw grain 0.02, early grain 0.03, young Grain 0.23, late grain 0.27, lobed 0.34, diagnosed as chronic myelogenous leukemia (Chr). After treatment with Maryland, the symptoms were relieved, and the spleen was obviously retracted and discharged. At the beginning of October 1985, fatigue and dizziness appeared again. More than half of the bone pain, the hospitalized treatment with Marlyn was ineffective. After treatment with 1,2:5,6-dihydroestradiol (DAG), the symptoms were relieved and discharged. Due to fever, bone pain, bloating, and mucocutaneous bleeding, 1 week , On July 21, 1986, he went to the hospital again and was admitted to “Cranial Rapid Change.”