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Ｔ淋巴细胞源性细胞因子可介导或调节多种免疫应答，γ但细胞因子表达缺陷、失衡或调节异常与免疫缺陷病有关，患者见有ＩＬ－２、－３、－４、－５、ＩＦＮγ等表达降低或过量合成，新生儿的生理性免疫缺陷则因未接触过抗原，也表现上述现象，这与体内缺乏相应记忆性Ｔ细胞相关。从基因结构和基因转录水平分析，上述多种细胞因子基因关键序列的甲基化程度和启动子中调节因素的差异导致相应ｍＲＮＡ合成量下降。临床实例也阐明细胞因子产生缺陷和失衡与免疫缺陷有关系。该资料为深入了解免疫系统的正常发育和人类原发性免疫缺陷提供有益的信息。
T-lymphocyte-derived cytokines may mediate or regulate a variety of immune responses, γ but defects, imbalances or abnormalities of cytokine expression are associated with immunodeficiency disorders, including IL-2, -3, -4, -5, IFNγ expression such as reduced or excessive synthesis of neonatal physiological immunodeficiency due to untreated antigen, also demonstrated the phenomenon, which is related to the lack of corresponding memory T cells in vivo. From the analysis of gene structure and gene transcription level, the differences of the methylation degree of key sequences of the above-mentioned cytokines genes and the regulatory factors in the promoter lead to the decrease of the corresponding mRNA synthesis. Clinical examples also illustrate that cytokine production defects and imbalances are associated with immunodeficiency. This data provides useful information for further understanding of the normal development of the immune system and human primary immune deficiency.