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测定８９例癌症患者血清硒（ＳＳｅ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活性，并与３１例健康人进行对照，以探讨ＳＳｅ与ＧＳＨ－ＰＸ间的相互关系和临床意义。结果示ＳＳｅ与ＧＳＨ－ＰＸ活性明显低于对照组（Ｐ＜０．０１和Ｐ＜０．０５），ＳＳｅ和ＧＳＨ－ＰＸ呈显著正相关。随着临床分期不同，ＳＳｅ和ＧＳＨ－ＰＸ活性下降趋于明显，Ⅲ～Ⅳ期明显低于Ⅰ－Ⅱ期（Ｐ＜０．０５）；不同部位癌症患者之间ＳＳｅ和ＧＳＨ－ＰＸ活性均无显著性差异（Ｐ＞０．５）。提示ＳＳｅ和ＧＳＨ－ＰＸ活性与癌症的发展有关
The serum selenium (SSe) and whole blood glutathione peroxidase (GSH-PX) activity were measured in 89 cancer patients and compared with 31 healthy subjects to explore the relationship between SSe and GSH-PX and clinical significance. The results showed that the activity of SSe and GSH-PX was significantly lower than that of the control group (P<0.01 and P<0.05), and there was a significant positive correlation between SSe and GSH-PX. With the different clinical stages, the activity of SSe and GSH-PX decreased significantly, and it was significantly lower in stage III-IV than in stage I-II (P<0.05). No activity of SSe and GSH-PX was found between cancer patients at different sites. Significant difference (P>0.5). It suggests that SSe and GSH-PX activity is related to the development of cancer