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目的了解安徽省接受抗病毒治疗(ART)的艾滋病(AIDS)病人的服药依从性及其相关影响因素,为提高AIDS病人的治疗依从性提供参考。方法在部分市及县区的重点乡镇,整群抽取接受ART的AIDS病人进行横断面调查,收集病人的一般人口学、服药和治疗情况等信息进行分析。结果共调查801例AIDS病人,男性480人(59.9%),女性321人(40.1%);平均年龄为(44.5±10.9)岁(18~73岁)。既往采供血感染389人(48.6%),经性传播感染361人(45.1%)。最近1个月漏服过药物的有98人,占12.2%,最近1个月漏服药超过2次的有21人,占2.6%(即服药依从性>95%的占97.4%)。多因素Logistic回归分析显示,年龄低、饮酒和有药物不良反应,可能是服药依从性的影响因素。结论安徽省接受ART的AIDS病人的服药依从性整体状况较好,但仍需进一步巩固和提高,在今后工作中应注意对年龄较小、有饮酒习惯和发生药物不良反应的病人加强服药依从性教育。
Objective To understand the medication adherence of AIDS patients receiving antiviral therapy (ART) in Anhui Province and its related influencing factors, so as to provide reference for improving the adherence of AIDS patients. Methods In the key townships of some cities and counties, the AIDS patients receiving ART were enrolled in the cluster to carry out cross-sectional surveys to collect the general demographic, medication and treatment information of patients. Results A total of 801 AIDS patients were surveyed, 480 males (59.9%) and 321 females (40.1%) with an average age of (44.5 ± 10.9) years (18-73 years). In the past, 389 people were infected with blood supply (48.6%) and 361 (45.1%) were sexually transmitted. In the most recent month, 98 people missed medication, accounting for 12.2%. In the most recent month, 21 people missed medication more than 2 times, accounting for 2.6% (97.4% of those with compliance> 95%). Multivariate Logistic regression analysis showed that low age, alcohol consumption and adverse drug reactions may be medication compliance factors. Conclusion Anhui patient receiving better medication compliance AIDS patients overall condition of ART, but still need to be further consolidated and improved in the future work should pay attention to the younger, have drinking habits and adverse drug reactions of strengthening medication compliance education.