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目的:探讨唾液分泌型免疫球蛋白A(sIgA)在幽门螺杆菌(HP)感染中对机体的保护作用。方法:应用尿素酶快速检测法检测79例胃和十二指肠炎症、溃疡病人的HP感染情况。同时应用放射免疫法测定唾液及胃液中分泌型免疫球蛋白A(sIgA)、免疫球蛋白G(IgG)浓度。结果:HP检出率70.9%,(56/79)。HP阴性组(n=23)唾液sIgA浓度为(54.41±29.99)mg/L,高于阳性组(n=56)的(37.25±19.25)mg/L(t=2.016 7,P<0.05)。两组中唾液sIgA浓度均明显高于胃液中浓度。胃液中sIgA,唾液及胃液IgG浓度两组间无显著性差异。结论:以上结果显示唾液sIgA在抗幽门螺杆菌感染中可能对机体产生保护作用。
Objective: To investigate the protective effects of salivary secreted immunoglobulin A (sIgA) on Helicobacter pylori (HP) infection. Methods: Rapid detection of urease was used to detect HP infection in 79 patients with gastric and duodenal inflammation and ulcer. At the same time, the concentrations of secretory immunoglobulin A (sIgA) and immunoglobulin G (IgG) in saliva and gastric juice were determined by radioimmunoassay. Results: The detection rate of HP was 70.9% (56/79). The salivary sIgA concentration was (54.41 ± 29.99) mg / L in HP negative group (n = 23), which was higher than that of positive group (n = 56) (37.25 ± 19.25 mg / L, t = 2.0167, P <0.05). The salivary sIgA concentrations in both groups were significantly higher than those in gastric juice. Gastric juice sIgA, saliva and gastric IgG concentration between the two groups no significant difference. CONCLUSIONS: The above results show that salivary sIgA may have protective effects against H. pylori infection.