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他克莫司作为一种强效免疫抑制剂,被广泛应用于肾移植术后的抗排斥治疗。但其治疗窗窄,血药浓度个体差异大,且移植术后各时间段的目标浓度范围不同,需密切监测血药浓度,以期保证疗效,减少不良反应的发生。笔者全面探讨肾移植术后患者他克莫司血药浓度的影响因素,为他克莫司的治疗药物监测和剂量调整提供参考。
As a potent immunosuppressive agent, tacrolimus is widely used in anti-rejection therapy after renal transplantation. However, the therapeutic window is narrow and the plasma concentration varies greatly between individuals. After the transplantation, the target concentration range varies from time to time. The blood concentration should be closely monitored in order to ensure the curative effect and reduce the adverse reactions. The author comprehensively explores the influencing factors of tacrolimus plasma concentration in patients after renal transplantation, and provides a reference for tacrolimus treatment drug monitoring and dose adjustment.