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茯苓是应用十分广泛的药用真菌.中国医学科学院抗菌素研究所从茯苓多糖粗提物中提取出一组小分子化合物,命名为茯苓素(F_(101)),具有抑制肿瘤细胞增殖和激活小鼠腹腔巨噬细胞的作用.许多实验证明,有效的分化诱导剂诱导白血病细胞分化与抑制细胞增殖之间存在一定的联系.这促使我们用抗菌素研究所许津教授提供的F_(101)进行对HL-60细胞分化诱导的研究,发现F_(101)不仅可抑制HL-60细胞的增殖,也诱导其分化为单核-巨噬样细
Radon is a widely used medicinal fungus. Institute of Antibiotics, Chinese Academy of Medical Sciences Extracts a group of small molecule compounds from the crude extract of Polysaccharides of Polygonum stramonium, named as alizarin (F_(101)), which can inhibit the proliferation and activation of tumor cells. The role of murine peritoneal macrophages. Many experiments have shown that there is a link between effective differentiation inducer-induced differentiation of leukemia cells and inhibition of cell proliferation. This prompted us to use the F_(101) provided by Prof. Xu Jin from the Institute of Antibiotics. Studies on the induction of differentiation of HL-60 cells revealed that F_(101) not only inhibited the proliferation of HL-60 cells, but also induced its differentiation into mononuclear-macrophages.