台湾是HBV传染的高发区,估计有30-50％的HBsAg慢性携带者是由围产期传染的结果。携带HBsAg的母亲所生婴儿,3个月内,大约有三分之一变成HBsAg阳性。如果这些母亲又是HBeAg阳性,其婴儿的感染率增加到90％。一旦婴儿变成HBsAg阳性,在6-9个月期间,阳性率大约是90％,最终大多数将变成慢性携带者。在台湾每年的新生儿有35万到40万,其中7万多是由慢性 Taiwan is a high incidence of HBV infection and an estimated 30-50% of chronic carriers of HBsAg are the result of perinatal infection. About one third of HBsAg-positive mothers give birth to HBsAg within 3 months. If these mothers are HBeAg-positive, their infant’s infection rate increases to 90%. Once the baby becomes HBsAg positive, the positive rate is about 90% over the 6-9 months, and eventually most will become chronic carriers. There are between 350,000 and 400,000 newborns in Taiwan every year, of which more than 70,000 are chronic