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1目的 探讨 GST-π表达与乳腺癌生物特性的关系。 2方法 利用 GST-π抗体的免疫组化方法检测了 38例乳腺癌、2 9例乳腺良性肿瘤患者组织 GST-π的表达。 3结果 乳腺癌患者组织 GST-π的阳性率为 81.6 %,明显高于乳腺良性肿瘤 (41.4%)。GST-π表达与乳腺癌患者的年龄、临床期别、肿瘤大小及有无腋淋巴结转移等无关 ,而与雌、孕激素受体状态呈负相关。 4结论 检测乳癌患者组织 GST-π表达对乳腺癌的早期诊断和预后判断具有一定的临床意义
Objective To investigate the relationship between GST-π expression and biological characteristics of breast cancer. 2 Methods GST-π antibody immunohistochemistry was used to detect the expression of GST-π in 38 cases of breast cancer and 29 cases of benign breast tumors. 3 Results The positive rate of GST-π in breast cancer patients was 81.6%, which was significantly higher than that of benign breast tumors (41.4%). The expression of GST-π was not related to the age, clinical stage, tumor size and axillary lymph node metastasis of breast cancer patients, but negatively related to the status of estrogen and progesterone receptors. 4 Conclusion Detection of GST-π expression in breast cancer patients has certain clinical significance in the early diagnosis and prognosis of breast cancer.