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J.Am.Chem.Soc.2015,137,3787~3790氮杂七元环尤其是含氮杂七元环的多环并环骨架广泛存在于天然产物和药物分子中.对其的合成,利用传统的方法需要多步合成才能实现且存在底物普适性不好、反应条件苛刻等缺点.此外,通过环加成反应实现对这类化合物的不对称合成的例子未见报道.华东师范大学化学与分子工程学院冯见君老师、吴海虹教授和张俊良教授合作,创新性地将烯基氮杂环丙烷引入到杂[5+2]环加成反应中,使用[Rh(NBD)2]+BF4-催化剂首次实现了烯基氮杂环丙
J.Am.Chem.Soc.2015,137,3787 ~ 3790Aza seven-membered ring, in particular a seven-membered heterocyclic ring containing a plurality of heterocyclic ring-wide ring exists in natural products and drug molecules.For its synthesis, use Traditional methods require multi-step synthesis in order to achieve and there are disadvantages of poor substrate universality, harsh reaction conditions, etc. In addition, the asymmetric synthesis of these compounds via cycloaddition reaction has not been reported yet.East China Normal University Faculty of Chemistry and Molecular Engineering Professor Feng Jianjun, Professor Wu Haihong and Professor Zhang Junliang have been working together to introduce enazetidine into hetero [5 + 2] cycloadditions using [Rh (NBD) 2] + BF4- The first realization of the alkenyl alkenyl aziridine