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肿瘤坏死因子(TNF)被认为是在重症应激反应中,致成各种病理生理过程的最重要的细胞因子之一。为消除内毒素诱导内源性TNF和其它因素影响,直接了解大剂量TNF(100μg/kg/天)对机体危害作用,应用人重组TNF致伤无菌大鼠,观察其对无菌大鼠的全身影响。致伤组48小时处死后大体解剖发现:肺气肿、充血、肺
Tumor necrosis factor (TNF) is considered to be one of the most important cytokines that cause various pathophysiological processes in severe stress reactions. In order to eliminate the influence of endotoxin-induced endogenous TNF and other factors, a direct understanding of the role of high-dose TNF (100μg/kg/day) on the body, the application of human recombinant TNF injury in sterile rats, observed its effect on sterile rats Systemic influence. Gross anatomy findings after 48-hour mortality in the wounded group: emphysema, congestion, lung