五元螺环氧化吲哚骨架广泛存在于天然产物及药物活性分子当中,但其结构复杂且在合成过程中立体选择性难以控制,因此成为有机化学家研究的热点与难点.近年来,有机催化的串联反应得到了蓬勃发展,逐渐成为高效合成具有复杂骨架化合物的强有力策略.复旦大学化学系孙强盛、孙兴文等从一些简单易得的原料出发,在低加载量 The pentasil spiro oxide indole skeleton exists widely in natural products and active pharmaceutical molecules, but its structure is complex and its stereoselectivity is difficult to control in the synthesis process, so it has become a hot and difficult issue for organic chemists.In recent years, organic Catalytic tandem reaction has been booming, and has gradually become a powerful strategy for the efficient synthesis of complex scaffold compounds.Sun Qinsheng, Sun Xingwen, Fudan University, Department of Chemistry from some simple and readily available raw materials, low load