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目的:探讨抗流感合剂治疗流行性感冒的临床疗效。方法:选取本院2013年4月-2014年4月治疗的流行性感冒患者150例作为研究对象,随机分为观察组和对照组。对照组采取利巴韦林,出现高热患者,可采取扑热息痛治疗;观察组采取抗流感合剂治疗;对比两组患者治疗前后的免疫学指标白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)的表达水平,综合评价患者的临床疗效。结果:观察组治疗后,LI-1、LI-6及TNF-α表达水平较治疗前,均显著降低;而LI-10表达水平较治疗前,显著升高;差异具有统计学意义(P<0.05);对照组治疗前后的免疫学指标表达水平比较,差异无统计学意义(P>0.05);两组患者治疗前的免疫学指标表达水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的LI-1、LI-6和TNF-α表达水平均显著低于对照组,LI-10表达水平显著高于对照组(P<0.05);观察组临床总有效率为93.33%,对照组临床总有效率为80.00%;组间比较,差异具有统计学意义(P<0.05)。结论:抗流感合剂治疗流行性感冒的临床疗效确切,通过降低LI-1、LI-6及TNF-α表达水平,提高LI-10表达水平,对免疫炎症损伤进行干预修复,显著改善患者的预后。
Objective: To investigate the clinical curative effect of anti-flu mixture in the treatment of influenza. Methods: A total of 150 patients with influenza who were treated in our hospital from April 2013 to April 2014 were selected as study subjects and randomly divided into observation group and control group. The control group was treated with ribavirin, patients with hyperthermia, can be treated with paracetamol; the observation group to take anti-flu mixture therapy; compared two groups of patients before and after treatment of immunological indicators of interleukin-1 (IL-1), interleukin- 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) Results: After treatment, the expression levels of LI-1, LI-6 and TNF-α in the observation group were significantly lower than those before treatment, while the expression level of LI-10 in the observation group was significantly higher than that before treatment; the difference was statistically significant (P < 0.05). There was no significant difference in the immunological indexes before and after treatment in the control group (P> 0.05). There was no significant difference in the immunological indexes between the two groups before treatment (P> 0.05). After treatment, the expression levels of LI-1, LI-6 and TNF-α in observation group were significantly lower than those in control group, and the expression level of LI-10 was significantly higher than that in control group (P <0.05). The total effective rate in observation group was 93.33% in the control group, and 80.00% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: The clinical curative effect of Kanglian Mixture in the treatment of influenza is accurate. It can improve the expression of LI-1, LI-6 and TNF-α, increase the expression of LI-10 and interfere and repair immunoinflammatory injury, which can significantly improve the prognosis .