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目的:研究肉桂水提液对大鼠全脑缺血再灌注损伤的保护作用。方法:健康SD雄性大鼠50只随机平均分5组:正常组、模型组和肉桂水提液低、中、高剂量给药组(10,20,40 g.kg-1)。采用4-血管阻断(4-VO)方法建立全脑缺血再灌注动物模型,造模前ig给药7 d,造模后3 h取材,利用分光光度法检测大鼠心、肝、脑、肾等组织中单胺氧化酶(MAO)和过氧化氢酶(CAT)的活力。结果:与模型组比较,肉桂水提液各剂量组均能显著降低各组织中MAO(P<0.05或P<0.01)的活力,并以低剂量组效果最佳;高剂量给药组能显著提高心、肝、脑、肾各组织中CAT活力(P<0.05或P<0.01);低剂量给药组和中剂量给药组对提高心、脑组织中的CAT活力具有一定的显著性差异(P<0.01或P<0.05),但对提高肝、肾组织中的CAT活力没有显著性差异。结论:肉桂水提液对脑缺血再灌注损伤有保护作用,其机制可能与抗脂质过氧化和抑制单胺氧化酶活力有关。
Objective: To study the protective effect of cinnamon aqueous extract on global cerebral ischemia-reperfusion injury in rats. Methods: Fifty healthy SD male rats were randomly divided into five groups randomly: normal group, model group and aqueous extract of cinnamon (IO), medium and high dose groups (10, 20 and 40 g.kg-1). The animal model of global cerebral ischemia-reperfusion was established by 4-Vascular occlusion (4-VO). The rats were administered with ig for 7 days before modeling and 3 hours after the model was established. The contents of heart, liver and brain were detected by spectrophotometry , Kidney and other organizations, monoamine oxidase (MAO) and catalase (CAT) activity. Results: Compared with the model group, the cinnamon water extract of each dose group can significantly reduce the activity of MAO (P <0.05 or P <0.01), and the best effect in the low dose group; high dose group can significantly (P <0.05 or P <0.01). The low-dose group and medium-dose group had a significant difference in CAT activity in heart and brain tissue (P <0.01 or P <0.05), but there was no significant difference in improving CAT activity in liver and kidney. Conclusion: Cinnamon water extract has a protective effect on cerebral ischemia-reperfusion injury, and its mechanism may be related to anti-lipid peroxidation and inhibition of monoamine oxidase activity.