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采用3种方案:顺铂60～80mg;顺铂60～80mg加短小棒状杆菌4～6ml;非顺铂药物腔内灌注治疗晚期癌症患者恶性胸腹腔积液98例,以观察不同方案的疗效。结果:顺铂加短小棒状杆菌控制恶性胸腹腔积液有效率为90.9%,明显高于顺铂组62.2%和非顺铂组67.9%,有显著性差异(P<0.005和P<0.025),后两者无统计学差异(P>0.5)。12例原发性肝癌所致的腹腔积液均未能控制。提示除原发性肝癌腹腔积液外,顺铂加短小棒状杆菌腔内灌注是治疗晚期癌症恶性胸腹腔积液的一种有效方法。
Three protocols were used: Cisplatin 60 ~ 80mg; Cisplatin 60 ~ 80mg plus Corynebacterium parvum 4 ~ 6ml; Non-cisplatin intracavity infusion treatment of 98 cases of advanced cancer patients with malignant pleural effusion, to observe the efficacy of different programs. Results: The effective rate of cisplatin and Corynebacterium parvum in controlling malignant peritoneal effusion was 90.9%, which was significantly higher than that of 62.2% in cisplatin group and 67.9% in non-cisplatin group, with significant difference (P<0.005 and P<0.025). There was no statistical difference (P>0.5). The 12 cases of primary liver cancer caused by peritoneal effusion were not controlled. In addition to peritoneal effusion of primary liver cancer, cisplatin plus Corynebacterium parvum infusion is an effective method for the treatment of advanced cancer with malignant pleural effusion.