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患者因脾脏功能亢进作了脾脏切除术。脾活检报告系脾脏生发中心缺乏。脾脏切除后的3年期间,发生了9次暴发性感染。多次住院血培养均为肺炎双球菌。手术前后免疫学检查:血清IgA水平减低,IgM增高。手术后除CH50减低外,未见其他免疫球蛋白、C_3、E花环有任何改变。本文讨论了发生OPSI的一些可能因素,并复习了OPSI典型综合征和预防措施。作者建议把免疫功能缺陷列为脾切除禁忌症。
Patients were splenectomized due to hypersplenism. Spleen biopsy report lack of spleen germinal center. During the three years after splenectomy, nine outbreaks of infection occurred. Multiple hospital blood cultures are pneumococcus. Immunological examination before and after surgery: serum IgA levels decreased, IgM increased. In addition to CH50 after surgery to reduce, no other immunoglobulins, C_3, E garland any change. This article discusses some of the possible causes of OPSI and reviews typical Opsi syndromes and preventative measures. The authors suggest that the immune function defects as a contraindication for splenectomy.