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目的：比较不同剂量的氟伐他汀（ｆｌｕｖａｓｔａｔｉｎ）与普伐他汀（ｐｒａｖａｓｔａｔｉｎ）治疗原发性高胆固醇血症的疗效及安全性。方法：按随机双盲平行对照法，经４周安慰剂期后，将１２９例原发性高胆固醇血症的患者分成２组，经４周安慰剂期后；双盲期试验组口服氟伐他汀４０ｍｇ、每日１次，对照组口服普伐他汀２０ｍｇ、每日１次，疗程均为６周；增量双盲期根据血清总胆固醇情况两组部分患者加量、部分维持原剂量再用药６周。测定治疗前、中、后血清各项血脂指标及其它相关指标。结果：与治疗前相比，服药１２周后试验组总胆固醇均值下降１８％，低密度脂蛋白胆固醇均值下降２４％（Ｐ均＜０．００１）；甘油三酯均值下降１２％（Ｐ＜０．０５）；高密度脂蛋白胆固醇均值升高５％（Ｐ＜０．０５）。对照组总胆固醇均值下降２０％，低密度脂蛋白胆固醇均值下降３０％（Ｐ＜０．００１），甘油三酯均值下降１６％（Ｐ＜０．０１），高密度脂蛋白胆固醇均值升高１５％（Ｐ＜０．０１）。组间比较两者降低总胆固醇、甘油三酯和低密度脂蛋白胆固醇的作用在统计学上无显著差别（Ｐ＞０．０５）。两组副反应发生率分别为６．０％和４．２％（Ｐ＞０．０５）。主要表现为胃肠系统副反应，均可耐受?
Objective: To compare the efficacy and safety of different doses of fluvastatin and pravastatin in the treatment of primary hypercholesterolemia. Methods: According to a randomized, double-blind, parallel-controlled trial, 129 patients with primary hypercholesterolemia were divided into two groups after 4 weeks of placebo. After 4 weeks of placebo, patients in the double- Statin 40mg, 1 day, the control group oral pravastatin 20mg, 1 day, course of treatment were 6 weeks; incremental double-blind according to serum total cholesterol two groups of patients plus the amount of part of the original dose to maintain the original dose 6 weeks. Determination of serum lipids before, during and after treatment indicators and other related indicators. Results: After 12 weeks of treatment, the mean cholesterol of test group decreased by 18% and the average of LDL cholesterol decreased by 24% (P <0.001), mean of triglyceride decreased by 12% (P <0) .05); mean high-density lipoprotein cholesterol increased by 5% (P <0.05). In the control group, the mean total cholesterol was decreased by 20%, the average LDL cholesterol by 30% (P <0.001), the mean triglyceride by 16% (P <0.01), and the mean high density lipoprotein cholesterol % (P <0.01). There was no statistically significant difference between the two groups in the reduction of total cholesterol, triglyceride and low density lipoprotein cholesterol (P> 0.05). The incidence of side effects in both groups were 6.0% and 4.2%, respectively (P> 0.05). Mainly gastrointestinal side effects, can be tolerated?