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目的探讨急性白血病化疗后感染的科学合理的治疗对策。方法2003-04~2004-08应用美国感染疾病协会(IDSA)推荐的《中性粒细胞减少的癌症患者抗生素应用2002年指南》对河北医科大学第二医院血液内科近1年收治的106例初治急性白血病患者化疗后感染进行治疗。结果106例患者中94例经治疗后感染得到控制,12例患者发生多脏器功能衰竭(MODS)并最终导致死亡。感染难以控制的因素主要是年龄超过60岁及白血病细胞对化疗药物的原发耐药。结论应用IDSA推荐的“指南”合理应用抗生素,可显著改善急性白血病患者化疗后感染的预后。
Objective To investigate the scientific and rational treatment of acute leukemia infection after chemotherapy. Methods From 2003-04 to 2004-08, 106 patients with neutropenia in cancer patients treated with antibiotics recommended by the American Association for Infectious Diseases (IDSA) in 2002 were enrolled in the first year of Department of Hematology, Second Hospital of Hebei Medical University Treatment of acute leukemia patients after chemotherapy for infection. Results Ninety-four of 106 patients were treated for post-treatment infection, and 12 patients developed multiple organ failure (MODS) and eventually death. Infectious uncontrollable factors are mainly older than 60 years of age and leukemia cells of primary drug resistance to chemotherapy. Conclusion The rational use of antibiotics in the guideline recommended by IDSA can significantly improve the prognosis of patients with acute leukemia after chemotherapy.