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胎盘滋养细胞是妊娠过程中最活跃的细胞之一,其功能失调导致一系列的妊娠相关疾病。因此,滋养细胞成为研究妊娠相关疾病的焦点。细胞内信号转导与疾病关系的研究是揭开疾病发病机制的重要途径,丝裂素活化蛋白激酶(MAPK)是细胞内信号转导的重要途径,可能参与细胞生长、发育、分裂等多种生理过程,并在细胞恶性侵袭等病理生理过程中起重要的作用。妊娠期滋养细胞的MAPK通路可能对滋养细胞黏附、侵袭功能的影响起关键作用。
Placental trophoblast is one of the most active cells during pregnancy and its dysfunction leads to a series of pregnancy-related diseases. Therefore, trophoblasts become the focus of research on pregnancy-related diseases. The study of the relationship between intracellular signal transduction and disease is an important way to uncover the pathogenesis of the disease. Mitogen-activated protein kinase (MAPK) is an important pathway in intracellular signal transduction and may be involved in many kinds of cell growth, development and division Physiological processes, and plays an important role in pathophysiological processes such as cell malignant invasion. The gestational trophoblast MAPK pathway may play a key role in the influence of trophoblast adhesion and invasion function.