改变宿主正常防预机制的能力对病原菌的生存是重要的,这一点对细胞内寄生菌特别重要。这些细菌(如布氏菌等)能在宿主吞噬细胞内存活和生长,抵抗吞噬细胞内杀菌素的作用,是其生长的必须条件。为深入了解存活后的机理,作者检查了有毒和无毒牛种布氏菌提取物对防止巨噬细胞内吞噬溶酶体的融合作用。也检查了牛种布氏菌的脂多糖成分是否能影响巨噬细胞的这种功能。 The ability to alter the host’s normal preclinical mechanisms is important for the survival of the pathogen, which is particularly important for intracellular parasites. These bacteria (such as brucella, etc.) can survive and grow in the host phagocytes to resist the role of endocytosis spinosad is a necessary condition for its growth. To gain insight into the mechanism of survival, the authors examined the fusion of toxic and non-bovine brucella extracts against phagocytic lysosomes in macrophages. It was also examined whether the LPS content of bovine species affected macrophage function.