论文部分内容阅读
目的:了解沈阳地区健康体检人群超重、肥胖的现状，探讨影响超重、肥胖的相关因素及超重、肥胖对血脂、血糖水平等生化指标的影响。方法:选取中国医科大学附属盛京医院体检中心2019年1－10月健康体检者共6 065例，按体质量指数不同分为正常组、超重组、肥胖组，比较不同性别、年龄段间超重和肥胖情况的变化趋势，比较组间各项生化指标水平，并通过二分类logistic回归分析分别得出超重、肥胖的影响因素。结果:6 065例受检者中，正常、超重、肥胖人群分别占39.50%、41.85%、18.65%。随着年龄增加，超重、肥胖率呈升高趋势(χn 2＝118.958，n P<0.001)；男性超重、肥胖率(超重率47.45%、肥胖率24.64%)高于女性(超重率33.08%、肥胖率9.26%)，差异有统计学意义(χn 2＝577.176，n P＝0.000)。超重肥胖组血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、肌酐、尿酸、胱抑素C、谷草转氨酶、谷丙转氨酶、γ-谷氨酰转肽酶、碱性磷酸酶、前白蛋白、收缩压、舒张压水平均高于正常组，高密度脂蛋白胆固醇、载脂蛋白A1均低于正常组，两组均差异有统计学意义(n t＝13.904、7.668、0.057、9.710、19.723、12.840、27.840、15.880、8.368、22.986、18.382、10.924、17.283、23.378、8.033、29.782、18.937，均n P<0.001)。logistic回归分析显示年龄、性别、收缩压、高甘油三酯、血糖、载脂蛋白B、尿酸、胱抑素C、谷丙转氨酶、γ-谷氨酰转肽酶是影响超重、肥胖的危险因素，而高密度脂蛋白胆固醇、载脂蛋白A1、肌酐、谷草转氨酶是超重、肥胖的保护因素(Wald＝37.863、6.871、40.632、13.472、16.800、28.165、94.152、9.533、126.332、8.017、16.427、34.338、13.948、49.814，均n P<0.01)。n 结论:沈阳地区健康体检人群超重、肥胖率较高，应针对超重、肥胖的相关危险因素尽早采取干预措施，提高人群生活质量。“,”Objective:To understand the status of overweight and obesity in healthy people in Shenyang area, and to explore the related factors of overweight and obesity and the influence of overweight and obesity on biochemical indicators such as blood lipid and blood glucose level.Methods:A total of 6 065 healthy subjects in our physical examination center of Shengjing Hospital Affiliated to China Medical University from January 2019 to October 2019 were collected and divided into normal group, overweight group and obesity group according to different BMI.The distribution characteristics of overweight and obesity in different gender, age were analyzed, as well as the influence of overweight and obesity on blood glucose, blood lipid and other indicators.Logistic regression was served to analyze the influence factors of overweight and obesity.Results:Among the 6 065 subjects, the prevalence of normal, overweight and obesity was 39.50%, 41.85% and 18.65%, respectively.The prevalence of overweight and obesity tended to rise with the increase of age(χn 2=118.958, n P<0.001). The overweight and obesity rates of men(47.45%, 24.64%) were higher than those of women(33.08%, 9.26%), and the difference was statistically significant (χn 2=577.176, n P=0.000). The levels of blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein B, creatinine, uricacid, cystatin C, glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, gamma-glutamyltransferase, alkaline phosphatase, prealbumin, systolic blood pressure and diastolic blood pressure in the overweight/obesity group were higher than those in the normal group, and the levels of high-density lipoprotein cholesterol and apolipoprotein A1 were lower than those in the normal group, the differences were statistically significant(n t=13.904, 7.668, 0.057, 9.710, 19.723, 12.840, 27.840, 15.880, 8.368, 22.986, 18.382, 10.924, 17.283, 23.378, 8.033, 29.782 and 18.937, all n P<0.001). Logistic regression analysis showed that the risk factors of overweight/obesity were age, gender, systolic blood pressure, triglyceride, blood glucose, apolipoprotein B, uricacid, cystatin C, glutamic-pyruvic transaminase, gamma-glutamyltransferase.High-density lipoprotein cholesterol, apolipoprotein A1, creatinine, glutamic-oxalacetic transaminase were the protective factors of overweight/obesity(Wald=37.863, 6.871, 40.632, 13.472, 16.800, 28.165, 94.152, 9.533, 126.332, 8.017, 16.427, 34.338, 13.948, 49.814, alln P<0.01).n Conclusion:The prevalence of overweight/obesity of the healthy people in Shenyang is high.We should take intervention measures as early as possible to improve the quality of life.