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进口药品阿波莫斯颗粒,是鸟氨酸与门冬氨酸的结合物,对肝细胞具有很好的保护作用,用于治疗肝炎及肝性疾病。厂方标准采用薄层色谱法,经茚三酮显色后进行扫描来测定制品的含量,该方法操作繁琐,影响因素较多,易造成误差。根据该药品的结构特点,我们建立了用氨基酸分析仪对阿波莫斯颗粒含量测定的方法。该方法灵敏度高,重现性好,结果准确,操作简便,而且可同时控制两种氨基酸的总量和含量比。
Imported drugs Ammos particles, is a combination of ornithine and aspartic acid, has a good protective effect on liver cells for the treatment of hepatitis and liver disease. The standard of the factory adopts thin-layer chromatography, and the content of the product is determined after being scanned by the ninhydrin color development. The method is cumbersome to operate and has many influencing factors and may easily cause errors. According to the structural features of the drug, we have established a method for the determination of the Abomeos particles using an amino acid analyzer. The method has high sensitivity, good reproducibility, accurate result and easy operation, and simultaneously controls the total amount and the content ratio of two amino acids.