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目的 :观察生脉注射液对阿霉素诱导大鼠心肌损伤的抗氧化作用。方法 :Wistar大鼠 30只 ,随机分为3组 ,每组 10只。生理盐水组腹腔注射生理盐水 5 ml· kg- 1 · d- 1 ,共 9日 ;阿霉素组腹腔注射阿霉素 3mg/ kg,隔日 1次 ,共 7日 ;生脉注射液组腹腔注射生脉注射液 5 ml· kg- 1 · d- 1 ,共 9日。到期测定血丙二醛 (MDA )含量和超氧化物歧化酶 (SOD)活性 ,并进行心肌病理检查。结果 :生脉注射液组与阿霉素组相比 ,血 SOD升高 ,MDA降低 ,心肌病理计分下降。结论 :生脉注射液有抗氧化作用和对阿霉素所引起的心脏毒性具有保护作用。
Objective : To observe the anti-oxidation effect of Shengmai injection on doxorubicin-induced myocardial injury in rats. Methods: Thirty Wistar rats were randomly divided into 3 groups with 10 in each group. Saline group was intraperitoneally injected with saline 5 ml·kg-1 · d-1 for 9 days; Adriamycin group was intraperitoneally injected with adriamycin 3 mg/kg every other day for 7 days; Shengmai injection was injected intraperitoneally. Shengmai Injection 5 ml· kg-1 · d-1 for a total of 9 days. The blood malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured at the expiration and myocardial pathological examinations were performed. Results: Compared with doxorubicin group, Shengmai injection group had higher blood SOD, lower MDA, and lower myocardial pathological score. Conclusion: Shengmai injection has anti-oxidation effect and has a protective effect on cardiotoxicity induced by doxorubicin.